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12 We leave out many small details in what follows. Poor metabolizers (PM), 122 Portals of entry, 4, 537 Potentiation-see Synergism and potentiation Pregnancy, effects on metabolism, 171 Pregnane X receptor (PXR), 196, 197 Pregnenolone-16α-carbonitrile, 191 Prevention of toxicity, 411421 Primitive streak, 252 Procarcinogen-see Carcinogen Procedural manuals, 24 Progesterone, 119 Progression, 241 Proguanil, 122 Promazine, 265 Promethazine, 129 Promotion, 241243, 537 Promoter insertion, 245 Propanolol, 138 Propiconazole, 310 Propofol, 122 Prospective assessment, 479480 Prostaglandins, 132, 274 Prostaglandin synthase, 132, and cooxidation, 112 Protein binding, 97, 270 effects on metabolism, 163 stabilization, 198 synthesis, 17, 264, 266 Proto-oncogene, 245 Pulmonary toxicity-see Toxicity Puromycin, 265 Pyrethroid insecticides, 61, 222, 477 Pyridoxine, 165, 166 Pyrrolizidine alkaloids, 265 Physicochemical properties, and diffusion, 8588 Q QAQC manuals, 24 QSAR-see Quantitative structure activity relationships Quality assurance, 27 Quality control, 27 Quantitation, 26 Quantitative structure activity relationships (QSAR), 537 Quinidine, 123, 187 Quinones, 151 R Radiation, 237 Radioimmunoassay, 21 Rainbow trout, 394 Rapamycin, 123 Ras, 246247 RCRA-see Resource Conservation and Recovery Act Reactive oxygen, 149, 151, 267, 322 Reactive intermediates (metabolites), 149161, 269, 538 Receptors androgen, 309 ecdysone, 307 ecological, 505506, 508 estrogen, 303, 306, 308 glucocorticoid, 309 hormone receptor agonists, 306 hormone receptor antagonists, 308 nuclear, 302303 retinoic acid, 307 retinoid X (RXR), 195, 196, 304, 308, 315 steroid, 303 thyroid, 303 Red book, 367 Reduction reactions, 133135 Reference Dose (RfD)-see Acceptable Daily Intake Regulation, of toxic chemicals, 353354, 411 Regulatory agencies, 354 Renal elimination, 205207 Renal system-see also Kidney blood flow, 274 cortex, 273 function, 273 structure, 273 susceptibility, 274275 tubules, 273, 274, 275 Renin, 274 Reproductive physiology female, 346347 male, 343344 Reproductive toxicants-see Toxicants Reproductive toxicity-see Toxicity Resistance-see Adaptation to toxicants Resource Conservation and Recovery Act (RCRA), 414, 538 Respiratory system anatomy, 317 and elimination, 210 cell types, 317 function, 317 INDEX 553 9.

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